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The show opened with the self-deprecating humor we've come to love from David Letterman, with a Presidential send-off.
His monologue was just as funny as ever where he planned for his coming retirement.
The highlight of the show was Dave's final Top Ten list, featuring some of his most frequent guests.
He took the time to thank everyone involved in the show, from the crew to the orchestra to the fans at home.
And the show ended with a very special performance from Foo Fighters.
Goodbye David Letterman, we'll miss you!